In contrast, among group A 1A 1 and A 1O 1 individuals, there was no relationship between AvWF and plasma vWF levels. In group O and group A 2O 1 individuals, HvWF was inversely correlated with plasma vWF levels. Among group A individuals, the pattern of HvWF expression was A 2O 1> A 1O 1> A 1A 1. H antigen expression per unit vWF ( HvWF) was highest in group O individuals. Thus, we have clearly demonstrated a direct relationship between ABO genotype, A transferase expression, and the amount of A antigen expressed on circulating vWF. AvWF was correlated strongly with plasma levels of A transferase activity. Plasma A transferase activity and the amount of A antigen expressed per unit vWF ( AvWF) were significantly higher in A 1A 1 than in A 1O 1 individuals and higher in A 1O 1 than in A 2O 1 individuals. vWF antigen (vWF:Ag) and factor VIII antigen (FVIII:Ag) levels were highest in A 1A 1 individuals and higher in A 1O 1 than in A 2O 1 or O 1O 1 individuals. To investigate whether the effect of ABO blood group on plasma von Willebrand factor (vWF) levels is mediated by the ABH antigenic determinants carried on N-linked glycans of vWF, we studied 158 group A and group O healthy volunteers.

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Half life 2 abh